Type d’annonce: Proposition – PostDoc
Description de la proposition:
Current surgical biopsy takes several days to be analyzed by anatomopathologists, who provide analysis report to the surgeon a few days after the surgical intervention. Moreover, tissue biopsies are often associated with patient discomfort as they are highly invasive. In addition, the lack of precise guidance often leads to inaccuracies in the selection of tissue regions for biopsy. Eliminating this time consuming process of conventional biopsy is a clinical need, as well as increasing the accuracy tissue diagnostics and the patient comfort. We propose to address these needs by developing a nonlinear endomicroscope able to give optical biopsy results on the spot, which will lead to the immediate diagnosis and an orientation of the choice for optimal therapy means. It will also limit the extraction of tissue sample for conventional biopsy analysis. In this instrument we will combine different imaging contrasts, including nonlinear optical fluorescence imaging (TPF), second harmonic generation (SHG), reflectance, lifetime and spectroscopic analysis. This multimodality is crucial to allow a reliable analysis of optical signal by anatomopathologist in comparison to the gold standard Hematoxilin and Eosin histological analysis. Fibered endomicroscope could be used during the surgical operation thus offering deep subcellular resolution without adding invasivity.
The recruited post-doc will be involved exclusively in the optical part of the project. It will be focalized on the study of the choice of the adapted miniaturized optics to the specific microstructured fiber. He/She will participate to the assembling and characterization of a customized DCF with this optics. He/She will be in charge to validate of the global collection architecture of the endomicroscope systems in term of efficiency and multimodality. In parallel, he/she will be involved in scanning system assembly.
The project is funded by the PlanCancer and is in collaboration with XLIM laboratory and Sainte Anne Hospital. The position can start in February 1st 2015 or later, and will be located at IMNC lab, Orsay, France.
– PhD in physics or medical imaging.
– Strong experience in optical instrumentation and optical fiber.
– Knowledge in fluorescence tissue imaging is welcome.
– Skill of Matlab, labview and Zemax for optical design will be appreciated
– 1 year
– A possibility for a prolongation of 6 months
Please send your candidature (CV + letter of motivation + 2 contact persons) to:
Darine ABI HAIDAR (firstname.lastname@example.org)
Proposé par: darine abi haidar
Adresse: Campus universitaire – bât 440, orsay, 91405, France
Details en pdf: http://gdr-miv.fr/gdr/wp-content/uploads/formidable/Postdoctoral-position-D.pdf